Recent Research Advances in Small-Molecule Pan-PIM Inhibitors

PIM kinase is consequently emerging as a promising target for cancer therapeutics and immunomodulation. kinases are overexpressed in variety of hematological malignancies solid tumors, their inhibition has become strong therapeutic interest. Currently, some pan-PIM inhibitors being developed under different phases clinical trials. Based on the scaffold structures, they can be classified into various subclasses. The X-ray structure complex outlines rationale hit compound confirmation early stage. Structure–activity relationships allow us to rationally explore chemical space further optimize multiple physicochemical biological properties. This review focuses discovery development small-molecule current research, hopes provide guidance future exploration inhibitors.